Gene induction by the USP6 oncogene in response to interferon. Gene induction by the USP6 oncogene in response to interferon

We examined the role of the USP6 oncogene in the patient-derived immortalized ewing sarcoma cell line RD-ES. RNA-sequncing revealed that USP6 induces numerous genes that overlap with genes induced by interferon treatment. When USP6-expressing cells were treated with IFN, many of the overlapping genes were synergistically upregulated, indicating an overlap in signaling pathways. Overall design: Examine the effects of USP6 and/or IFN on gene induction in RD-ES cells