Gene expression correlates of HIV-1 susceptibility and gene expression changes following HIV-1 infection

We sought to determine how gene expression changes during the first two years of HIV-1 infection among participants from HIV-1 serodiscordant couple cohorts from sub-Saharan Africa. This study included whole blood samples from 26 participants who did not have HIV-1 at study enrollment, had a steady sexual relationship with a partner with HIV-1 and acquired HIV-1 during follow-up. Most participants had samples from before and after infection. Gene expression was measured by Illumina HumanHT-12 v4 Expression BeadChips. Whole blood samples were preserved at -80 degrees C in PAXgene tubes. Samples were not replicated on the arrays.