Thromboxane signalling through TP receptor

Thromboxane (TXA2) binds to the thromboxane receptor (TP). There are 2 splice variant forms of TP, differing in their cytoplasmic carboxyl terminal tails. TP beta was first identified in endothelial cells. TP alpha was identified in platelets and placenta. The major signalling route for TP is Gq-mediated stimulation of PLC and consequent increase in cellular calcium. TP also couples to G13, leading to stimulation of Rho and Rac.

血栓素A2 (TXA2) 结合于血栓素A2受体 (TP)。TP存在两种剪接变异体形式，它们在细胞质羧基末端尾巴上有所不同。TP beta 首次在血管内皮细胞中被识别。TP alpha 则在血小板和胎盘中被发现。TP的主要信号传导途径是通过Gq介导的PLC激活，从而引起细胞内钙离子的增加。TP还与G13偶联，导致Rho和Rac的激活。