Mechanosensitive turnover of phosphoribosyl pyrophosphate synthetases regulates nucleotide metabolism
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Deletion of IXR1 leads to decreased dNTP levels.
(A) dNTP levels are decreased in ixr1Δ (TOY736), increased in ixr1Δ sml1Δ (TOY714) compared to wild-type (W1588-4C), but lower than in sml1Δ (U952-3B). Values shown are the average from two independen
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Effect of AICAR and SAICAR accumulation on global transcription (first part). Saccharomyces cerevisiae
We investigated the effects of AICAR and SAICAR accumulation on transcriptional regulation of purine biosynthesis and other metabolic pathways. In this work, global transcription analyses were combine
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Erk5 contributes to maintaining the balance of cellular nucleotide levels and erythropoiesis
An adequate supply of nucleotides is essential for accurate DNA replication, and inappropriate deoxyribonucleotide triphosphate (dNTP) concentrations can lead to replication stress, a common source of
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Data_Sheet_1_Studies on the Regulation of (p)ppGpp Metabolism and Its Perturbation Through the Over-Expression of Nudix Hydrolases in Escherichia coli.PDF
Stringent response mediated by modified guanosine nucleotides is conserved across bacteria and is regulated through the Rel/Spo functions. In Escherichia coli, RelA and SpoT proteins synthesize the mo
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Mechanisms of feedback regulation and drug resistance of CTP synthetases: structure of the E. coli CTPS/CTP complex at 2.8-Angstrom resolution.
Mechanisms of feedback regulation and drug resistance of CTP synthetases: structure of the E. coli CTPS/CTP complex at 2.8-Angstrom resolution. Descriptor: ADENOSINE-5'-DIPHOSPHATE, CTP synthase, CYTI
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