Additional file 9 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

Additional file 8 Gene lists and GO enrichment analyses for ATB- vs. Cont. transcriptome comparisons. (A) List of genes significantly up-regulated in males Pxr+/+ ATB compared to males Pxr+/+ Cont. (B) GO term enrichment analysis using the list of genes significantly up-regulated in males Pxr+/+ ATB compared to males Pxr+/+ Cont. Metabolic pathways were considered as significantly enriched when adjusted P-value < 0.05. (C) List of genes significantly down-regulated in males Pxr+/+ ATB compared to males Pxr+/+ Cont. (D) GO term enrichment analysis using the list of genes significantly down-regulated in males Pxr+/+ ATB compared to males Pxr+/+ Cont. Metabolic pathways were considered as significantly enriched when adjusted P-value < 0.05. (E) List of genes significantly up-regulated in males Pxr-/- ATB compared to males Pxr-/- Cont. (F) List of genes significantly down-regulated in males Pxr-/- ATB compared to males Pxr-/- Cont. (G) List of genes significantly up-regulated in females Pxr+/+ ATB compared to females Pxr+/+ Cont. (H) List of genes significantly down-regulated in females Pxr+/+ ATB compared to females Pxr+/+ Cont. (I) List of genes significantly up-regulated in females Pxr-/- ATB compared to females Pxr-/- Cont. (J) GO term enrichment analysis using the list of genes significantly down-regulated in females Pxr-/- ATB compared to males Pxr-/- Cont. No metabolic pathways was found significantly enriched at adjusted P-value < 0.05. (K) List of genes significantly down-regulated in females Pxr-/- ATB compared to females Pxr-/- Cont.