Sequencing_of_SW837_cells_following_CDS2_gRNA_transduction_and_selection
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https://www.ncbi.nlm.nih.gov/sra/ERP159013
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资源简介：
We further demonstrate that CDS1/CDS2 is a synthetic lethal interaction in vivo and reveal that CDS2 knockout results in the disruption of phosphoinositide synthesis, critical for the regulation of the MAPK and PI3K-Akt signalling pathways. We extend this analysis using pan-cancer data confirming increased CDS2 essentiality in diverse tumour types with low CDS1 expression. In this sequencing project we explore the genetic effects of CDS2 loss.
创建时间：
2025-04-16
