ARID1A deficiency promotes pancreatic tumorigenesis by reducing KRAS-induced senescence

NIAID Data Ecosystem2026-03-12 收录

胰腺癌肿瘤发生机制

基因调控与细胞衰老

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE160444 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2021-06-04

Mutant Kras co-opts a progenitor-derived enhancer network to initiate pancreatic tumorigenesis [scATAC-seq]

胰腺癌肿瘤发生机制

细胞染色质可及性分析

Oncogenes are highly specific in the cells they can transform, although the molecular basis for this is poorly understood. Inflammation often promotes tumorigenesis, and in the pancreas it promotes ce

NIAID Data Ecosystem170

Pancreatic epithelial IL-17/IL-17RA signaling drives B7-H4 to promote tumorigenesis

胰腺癌肿瘤发生机制

单细胞转录组学

IL-17 is required for the initiation and progression of pancreatic cancer, particularly in the context of inflammation, as previously shown by genetic and pharmacological approaches. The cellular comp

NIAID Data Ecosystem60

Long Noncoding RNA uc.345 promotes tumorigenesis of pancreatic cancer by upregulation of hnRNPL expression

胰腺癌肿瘤发生机制

非编码RNA功能

Increasing evidence points to an important functional or regulatory role of long noncoding RNA in cellular processes as well as some cancer diseases result from the aberrant lncRNA expression. LncRNA

NIAID Data Ecosystem50

Additional file 3 of The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer

胰腺癌肿瘤发生机制

EGF信号通路

Additional file 3: Table S2. Source files of bioinformatics analysis on EGFR (mainly TCGA PAAD datasets).

NIAID Data Ecosystem100

ARID1A deficiency promotes pancreatic tumorigenesis by reducing KRAS-induced senescence (RNA-Seq II). ARID1A deficiency promotes pancreatic tumorigenesis by reducing KRAS-induced senescence (RNA-Seq II)

胰腺癌肿瘤发生机制

ARID1A缺陷与衰老调控

ARID1A is one of the most frequently mutated epigenetic regulators in a wide spectrum of cancers. In this study, we identified the anti-senescence effect of ARID1A deficiency in the progression of pan

NIAID Data Ecosystem60

ARID1A deficiency promotes pancreatic tumorigenesis by reducing KRAS-induced senescence

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