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Visualizing Monogenic G-quadruplexes in Single Mammalian Cells

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP288144
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We developed a Module Assembled Multifunctional Probes Assay (MAMPA) for visualizing monogenic G4s in single cells. In order to verify RCAPs / Cell measured by mRNA RCA imaging is proportional to the mRNA relative expression in cells, the transcriptome of seven cell lines (MCF 10A, MDA-kb2, MCF-7, BT-474, SK-BR-3, MDA-MB-231, HeLa) has been analyzed by next-generation sequencing. The identity of the cells lines was authenticated with STR profiling. Three biological replicates and two technical replicates have been processed for each cell line.
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2020-10-26
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