Effect of Mas KO and a novel MAS agonist on pulmonary gene expression

Although both the Mas knockout and the Mas agonist affect roughly the expected types of genes (cytoskeletal, inflammatory, some metabolic), these data imply that (a) the agonist is under some circumstances an antagonist or partial agonist, and that (b) there is a redundant receptor which regulates nearly the same genes, present even with the Mas knockout. Pulmonary mRNA profiles of 200 day old male wild type (WT) and Mas-/- mice treated for 21 days with a MAS agonist or inactive vehicle control.