Alpha7-nicotinic acetylcholine receptor bound to epibatidine and ivermectin

Alpha7-nicotinic acetylcholine receptor bound to epibatidine and ivermectin Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, ... Authors: Burke, S.M, Noviello, C.M, Hibbs, R.E. Deposit date: 2023-11-15 Release date: 2024-02-21 Last modified: 2025-05-14 Method: ELECTRON MICROSCOPY (2.3 Å) Cite: Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation. Cell, 187, 2024