RNA binding proteins (RBP) of the ZFP36 family limit the differentiation and effector functions of CD4 and CD8 T cells, but little is known of their expression or function in regulatory T cells (Treg)

NIAID Data Ecosystem50

Gene expression in Galectin-3 KO vs. WT CD8 T cells

T细胞免疫调节

肿瘤免疫治疗

The goal of this study was to examine differences in gene expression of tumor specific CD8 T cells in an in vivo tumor mouse model after inhibition of galectin-3 protein expression by genetic knockout

NIAID Data Ecosystem30

Intrinsic Plasma Cell Differentiation Defects in BENTA Patient B cells

细胞分化异常

免疫缺陷疾病

From purified naïve B cells from a BENTA patient cohort, we performed differential expression analysis by RNA-seq to show that BENTA B cells exhibit intrinsic defects in B cell differentiation with po

NIAID Data Ecosystem60

Transcriptome analysis of antigen-specific T follicular helper (Tfh) and non-Tfh cells after Bach2 overexpression. Transcriptome analysis of antigen-specific T follicular helper (Tfh) and non-Tfh cells after Bach2 overexpression

T细胞免疫调节

转录组学分析

We identified Bach2 as factor to be expressed at low levels in Tfh cells. Induced overexpression of Bach2 in the germinal center reaction results in loss of the Tfh cell population. RNA-seq of sorted

NIAID Data Ecosystem40