Crystal structure of MerTK kinase domain in complex with UNC2025
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Crystal structure of MerTK kinase domain in complex with UNC2025 Descriptor: 4-[2-(butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Pflug, A, Schimpl, M, McCoull, W, Nissink, J.W.M, Overman, R.C, Rawlins, P.B, Truman, C, Underwood, E, Warwicker, J, Winter-Holt, J. Deposit date: 2020-09-05 Release date: 2020-10-28 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.78 Å) Cite: A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding. Biochem.J., 477, 2020
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2020-09-05
