Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq time series]. Genomic adaptation underlies nutrient-driven reprogramming in malaria parasite [tRNA-Seq time series]

We aimed to simultaneously characterize the dynamics of the codon and anti-codon pools during the intraerythrocytic developmental cycle Overall design: TGIRT-tRNAseq was performed on rings, trophozoites and schizonts with 3 replicates each, the anti-codon composition in the samples were then estimated from the read counts, charged level of each tRNA was estimated from a separate library with RNA pretreated with 50mM sodium periodate, pH4.8