Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic-Acid-Modified Pyridine and Triphenylphosphine Ligands

Pyridine- and phosphine-based ligands
modified with ethacrynic
acid (a broad acting glutathione transferase inhibitor) were prepared
and coordinated to ruthenium­(II)–arene complexes and to a ruthenium­(III)
NAMI-A type complex. All the compounds (ligands and complexes) were
fully characterized by analytical and spectroscopic methods and, in
one case, by single-crystal X-ray diffraction. The in vitro anticancer
activity of the compounds was studied, with the compounds displaying
moderate cytotoxicity toward the human ovarian cancer cell lines.
All the complexes led to similar levels of residual GST activity in
the different cell lines, irrespective of the stability of the Ru–ligand
bond.