Data from: Spatially targeted inhibitory rhythms differentially affect neuronal integration

This dataset contains simulation output from a biophysical model of a
cortical pyramidal neuron receiving excitatory Poisson input and
inhibitory input that was either Poisson or rhythmically modulated. The
simulations investigated how beta (16 Hz) and gamma (64 Hz) inhibitory
rhythms targeted to different dendritic compartments (distal dendrites vs.
perisomatic region) differentially affect dendritic spike generation and
somatic action potential output. Key findings: - Beta (16 Hz) inhibition
on distal dendrites strongly entrains Ca²⁺, NMDA, and Na⁺ dendritic spikes
in a phase-dependent manner, with ~75% modulation depth. - Gamma (64 Hz)
inhibition on the perisomatic region minimally modulates dendritic spikes
but modulates action potential generation by shifting the somatic voltage
threshold via shunting. - Excitation/inhibition balance effects differ by
location: lagging perisomatic inhibition reduces firing, while lagging
distal inhibition decreases firing up to 125 ms lag then recovers. - Beta
is the fastest rhythm capable of coordinating dendritic spike entrainment
across the full dendritic tree. - Oscillatory bursts of both rhythms
reproduce their tonic effects within the first few burst cycles. -
Clustered excitatory inputs are bidirectionally modulated in a
location-dependent manner: beta modulates distal apical inputs, gamma
modulates proximal basal inputs.