Comprehensive Analysis of Quantitative Proteomics with DIA Mass Spectrometry and ceRNA Network in Intrahepatic Cholestasis of Pregnancy

In this study, we analyze protein expression in placenta of ICP and normal pregnancies via quantitative proteomics of data-independent acquisition (DIA). Our results showed that compared with normal placenta, the differentially expressed proteins in ICP were involved in autophagosome regulation. Among the top 24 differentially expressed proteins, HBG1, SPI1, HBG2, HBE1, FOXK1, KRT72, SLC13A3, MBD2, SP9, GPLD1, MYH7 and BLOC1S1 were associated with ICP development significantly, furthermore, MBD2, SPI1, FOXK1, SLC13A3 was regulated by multiple miRNAs and lncRNAs. On the whole, our study on ICP might provide potential drug targets to improve adverse pregnancy outcomes of ICP patients.