PRMT5 is essential for sustaining normal adlut hematopoiesis

Examining the effects of PRMT5 loss on the gene expression profile of hematopoietic stem and progenitor cells Overall design: We established the PRMT5 conditional KO mice, and bred the mice with Mx1 cre transgenic mice to delete PRMT5 in hematopoietic cells. We isolated hematopoetic stem and progenitor cells 3 days after PRMT5 deletion, and examined the gene expression files using RNA-sequencing.