Mucoadhesive polymer-coated liposomes

This dataset contains data collected in the project “Development of nanoparticles for the treatment of emerging infections” funded by EU within the NextGeneration EU-MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases (Project no. PE00000007, INF-ACT) - CUP: J33C22002870005. Among all vaginal infectious diseases, aerobic vaginitis (AV) has high rates of recurrence, due to low treatment efficacy. AV is characterized by the overgrowth of aerobic microbes, a possible local pH increase and high inflammation. Local administration of antibiotics through conventional dosage forms usually leads to poor drug delivery or inadequate drug accumulation at the infection site, needing multiple administrations and increasing the risk of antibiotic resistance. In this context, nanocarriers, like liposomes, have shown peculiar advantages, including increasing the solubility of drugs and controlling their release. Furthermore, liposome-coating with mucoadhesive polymers could assure an increased drug residence time and favor its accumulation on mucosal-infected surfaces. In the present study, azithromycin (AZT)-containing liposomes, coated with two biocompatible polymers, chitosan and sodium hyaluronate, were developed with the final aim of controlling drug release, increasing drug retention time and accumulation in the vaginal mucosae. This dataset provides the data relative to the development and physical-chemical, microbiological and functional characterization of the LP formulations. Particularly, the dataset supplies raw data of vesicles size, polydispersity index, zeta-potential, encapsulation efficiency, in vitro drug release, mucoadhesion properties, antimicrobial activity, stability and in vitro drug permeation.