Auricular thumbtack needle combined with behavioral therapy for female patients with mild to moderate overactive bladder accompanied by anxiety symptoms： a randomized controlled trial

ObjectiveTo observe the effect of auricular thumbtack needle combined with behavioral therapy on anxiety symptoms， clinical symptoms， and peripheral serum 5-hydroxytryptamine （5-HT） content in female patients with mild to moderate overactive bladder （OAB） accompanied by anxiety symptoms.MethodsA total of 118 female patients with mild to moderate OAB and anxiety symptoms were randomly divided into an experimental group （59 cases， 10 dropouts） and a control group （59 cases， 2 dropouts）. In the control group， the behavioral therapy and basic treatment were provided. In the experimental group， auricular thumbtack needle therapy was given in addition to treatments in the control group. The thumbtack needles were applied to the auricular points of heart （CO15）， liver （CO12）， kidney （CO10）， and bladder （CO9）. Behavioral therapy was conducted daily， and the thumbtack needles were replaced every 3–4 days， alternating between both ears， for a total of 6 weeks. The following indicators were observed before and after treatment： overactive bladder symptom score （OABSS）， Hamilton anxiety scale （HAMA） score， overactive bladder questionnaire （OAB-q） score， Pittsburgh sleep quality index （PSQI） score， Hamilton depression scale （HAMD） score， traditional Chinese medicine （TCM） syndrome score， urodynamic parameters （maximum flow rate ［MFR］， maximum cystometric capacity ［MCC］， and residual urine volume ［RUV］）， nocturia frequency， and serum 5-HT content measured by ELISA.ResultsAfter 2， 4， and 6 weeks of treatment， the scores of OABSS， HAMA， OAB-q， PSQI， HAMD， and TCM syndrome scores in both groups decreased significantly （PPPPPPPConclusionOn the basis of behavioral therapy， combined with auricular thumbtack needle stimulation of the vagus nerve， it can effectively alleviate anxiety， improve clinical symptoms and nocturia in patients， and this therapy is safe in clinical application.