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Mouse ES cell line transcriptome changes upon replication stress. Mus musculus

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA415135
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To understand whether activation of ATR-dependent replication stress response could result in global transcriptional alterations similar to that of 2C-like cells, we performed whole transcriptional profiling on three mouse ESC lines, namely E14, R1 and MC1 upon aphidicolin treatment treatment or aphidicolin + ATR inhibitor treatment. For comparison we also did whole transcriptome profiling of the three cell lines without any treatment.
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2017-10-20
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