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The ubiquitin ligase HUWE1 regulates hematopoietic stem cell maintenance and lymphoid commitment. The ubiquitin ligase HUWE1 regulates hematopoietic stem cell maintenance and lymphoid commitment

NIAID Data Ecosystem2026-03-09 收录

造血干细胞调控

泛素连接酶

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA339518 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2016-08-19

单细胞转录组学

造血干细胞调控

Cellular decision-making is mediated by a complex interplay of external stimuli with the intracellular environment, in particular transcription factor regulatory networks. Here we have determined the

NIAID Data Ecosystem80

Renal Klotho and inorganic phosphate are extrinsic factors that antagonistically regulate hematopoietic stem cell maintenance

造血干细胞调控

分子生物学研究

The original, unprocessed western blot image of this paper submitted to Cell Reports.

NIAID Data Ecosystem60

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

RNA-蛋白质相互作用

泛素连接酶

TRIM25 E3 ubiquitin ligase is a new RNA-binding protein. We present the first high-throughput analysis of the molecular interactomes of TRIM25. We show that TRIM25 is a bona fide RNA-binding protein t

NIAID Data Ecosystem30

ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

造血干细胞调控

转录因子功能分析

To investigate the role of the transcription factor ERG in hematopoiesis we generated Erg heterozygous knockout and conditional Erg knockout mice. We found that several hematopoietic cell types were d

NIAID Data Ecosystem60

Gene expression profile of HSCs from Angptl2fl/fl or Cdh5-Cre;Angptl2fl/fl mice

造血干细胞调控

内皮细胞-干细胞信号转导

To identify the intracellular targets of endothelial cell-specific ANGPTL2 that control HSC stemness, HSCs from Angptl2fl/fl or Cdh5-Cre;Angptl2fl/fl were sorted, followed by the extraction of total

NIAID Data Ecosystem40

The ubiquitin ligase HUWE1 regulates hematopoietic stem cell maintenance and lymphoid commitment. The ubiquitin ligase HUWE1 regulates hematopoietic stem cell maintenance and lymphoid commitment

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