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S1 Fig. 2D structure of vaccine constituting alpha-helix, beta-turn, and coils. (A) 2D structure of vaccine V1 (B) 2D structure of vaccine V2. S2 Fig. Post-translational modification of vaccine construct. (A) Phosphorylation sites of vaccine V1 (B) Phosphorylation sites of vaccine V2. S3 Fig. Post-translational modification of vaccine construct. (A) Glycosylation sites of vaccine V1 (B) Glycosylation sites of vaccine V2. S4 Fig. Hydrogen bond analysis of the V1-TLR4 and V2-TLR5 complexes. S5 Fig. The time scale graph for MMPBSA during the MD simulation. (A) V1-TLR4 (B) V2-TLR5. S6 Fig. Normal mode analysis (NMA) evaluation of vaccine construct V1(A) Covariance (B) Variance (C) E-value (D) Elastic Network (E) Deformability (F) B-Factor. S7 Fig. Normal mode analysis (NMA) evaluation of vaccine construct V2(A) Covariance (B) Variance (C) E-value (D) Elastic Network (E) Deformability (F) B-Factor. S8 Fig. Confirmational B-cell epitopes of vaccine V1. (A) Confirmational B-cell epitopes of vaccine V1 through Discotop 3.0 (B) Confirmational B-cell epitopes of vaccine V1 through Ellipro. S9 Fig. Confirmational B-cell epitopes of vaccine V2. (A) Confirmational B-cell epitopes of vaccine V2 through Discotop 3.0 (B) Confirmational B-cell epitopes of vaccine V2 through Ellipro. S10. Fig. Immune simulation of vaccine V1 by C-Immsim Server. (A) Interleukins (B) B-cell population per state (C) Antigen Count (D) TH cell population per state (E) TC cell population per state (F) NK cell population per state. S11 Fig. Immune simulation of vaccine V2 by C-Immsim Server. (A) Interleukins (B) B-cell population per state (C) Antigen Count (D) TH cell population per state (E) TC cell population per state (F) NK cell population per state. (RAR)