Hg-MATE-Db.v1.01142021

<b>Hg-MATE-Db: Hg-</b>cycling<b> M</b>icroorganisms<b> </b>in<b> A</b>quatic<b> </b>and<b> T</b>errestrial<b> E</b>cosystems<b> D</b>ata<b>b</b>ase <br>Microorganisms play a significant role in regulating the form and fate of mercury (Hg) in aquatic and terrestrial ecosystems. Microbes with the <i>hgcAB</i> gene pair can produce a more toxic, and bioaccumulative form of Hg, methylmercury (MeHg). Microbes that possess the <i>mer</i> operon can demethylate and/or reduce Hg species as part of a detoxification mechanism. Improved techniques for capturing <i>hgcAB</i> and <i>mer </i>presence and diversity are necessary for identifying the major microbial players in environmental Hg cycling. The primary goal of the Hg-MATE-Db is to provide an up-to-date collated resource of Hg-cycling genes from pure culture and environmental microbial genomes and meta-omic datasets. The database will be updated regularly.<br><br>The Hg-MATE-Db.v1 contains an<b> </b><i>hgcAB </i>dataset with resources for identifying key microbial producers of the toxin MeHg. Future versions of the Hg-MATE-Db<b> </b>will also include <i>hgcAB</i> sequences from high-throughput sequencing and clone datasets. Future versions will also contain a <i>mer </i>dataset, which will contain resources for identifying genes of the <i>mer-</i>operon that encode for demethylation of organomercurials (<i>merB</i>), reduction of inorganic Hg(II) (<i>merA</i>), as well as operon regulation (<i>merR</i>), and Hg transport across the cell (<i>merTPC</i>).<br>The latest release, version 1 (v1), was compiled on 23 October 2020 and finalized on 14 January 2021, and contains an <i>hgcAB </i>dataset. The catalogue contains 1053 unique HgcA/B amino acid sequences. <br><br> Please cite us when using the Hg-MATE-Db in your work. Gionfriddo, C., Capo, E., Peterson, B., Lin, H., Jones, D., Bravo, AG., Bertilsson, S., Moreau, J., McMahon, K., Elias, D., and Gilmour, C. (2021). Hg-MATE-Db.v1.01142021. doi:10.25573/serc.13105370

搜集汇总

背景与挑战

背景概述

Hg-MATE-Db.v1.01142021是一个专注于汞循环微生物基因的数据库，当前版本包含1053个独特的HgcA/B氨基酸序列，主要用于识别环境中产生甲基汞的关键微生物。数据库将定期更新，未来计划扩展至mer操纵子等更多基因资源。