Aberrant DNA repair reveals a vulnerability in histone H3.3-mutant brain tumors
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Original data used in our work by Giacomini et al. including original microscopy images, western blot scans, quantifications of cell proliferation, results of proteomic and image analyses.We show that glioma-associated H3.3 mutations - K27M, G34R - trigger genome instability by altering DNA repair, and we reveal the first synthetic sick vulnerability of H3.3 mutant brain tumors based on a DNA repair enzyme.
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Polo, Sophie创建时间：
2023-12-14
