METTL3 promotes translation in human cancer cells. Homo sapiens
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA307106
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资源简介：
we find METTL3 associates with polyribosomes and promotes translation. METTL3 depletion inhibits translation, and both wild-type and catalytically inactive METTL3 promote translation when tethered to the 3' untranslated region (UTR) of a reporter mRNA. Mechanistically, METTL3 enhances mRNA translation through an interaction with the translation initiation machinery. Overall design: m6A seq in A549 and H1299 cells, RNA seq in METTL3 knockdown cells
创建时间：
2015-12-28
