Differential expression and mutant fitness are poorly correlated.

1Spearman rank correlation coefficient between fold change expression and fold change mutant abundance. More negative indicates a greater fitness contribution by up-regulated genes and/or a lesser fitness contribution by down-regulated genes. 2Number of genes considered is shown in parentheses. 3Differentially expressed (fold change ≥4, P<0.01, negative binomial test). 4Enzyme Commission.