Rhodium-Catalyzed Intermolecular Stereoselective Allylation of Indoles with Allenes

A rhodium-catalyzed C–H functionalization-based
intermolecular
allylation of indoles with trisubstituted allenes has been developed.
This synthetic process proceeds with an excellent regioselectivity, Z-selectivity, high efficiency of chirality transfer, and
a wide tolerance of reactive functional groups under mild conditions.
Late-stage modification on a series of complex bioactive or drug molecules
and various synthetic transformations has been demonstrated. A reaction
mechanism has been proposed on the basis of mechanistic experiments
and SAESI-MS studies.