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General and Direct Synthesis of 3-Aminoindolizines and Their Analogues via Pd/Cu-Catalyzed Sequential Cross-Coupling/Cycloisomerization Reactions

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NIAID Data Ecosystem2026-03-06 收录
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An efficient and one-step synthesis of 3-aminoindolizines or benz[e]indolizines from the reactions of propargyl amines or amides with heteroaryl bromides was developed. This methodology is realized by a tandem reaction using Pd/Cu catalysts, which could catalyze coupling and cycloisomerization reactions in the same vessel.

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2016-02-29
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