The aim of this investigation was to develop a global view of muscle transcriptional differences between older men and women and with aging for each sex. Muscle biopsies were obtained from the biceps
Gene expression changes during ageing were shown to oppose developmental trajectories; a reversal pattern previously linked to cellular identity loss. Generating cortex, lung, liver and muscle tissue
The rhesus macaque is an important non-human primate biomedical model of aging. Similar to humans, rhesus macaques show natural variability in age related pathologies. It is important to characterize
Aging is associated with substantial physiological changes and constitutes a major risk factor for neurological disorders including dementia. Alterations in gene expression upon aging have been extens
