Dataset related to article "Checkpoint inhibition before haploidentical transplantation with posttransplant cyclophosphamide in Hodgkin lymphoma"

This record contains data related to article "Checkpoint inhibition before haploidentical transplantation with posttransplant cyclophosphamide in Hodgkin lymphoma" We report on 59 Hodgkin lymphoma patients undergoing haploidentical stem cell<br> transplantation (SCT; haplo-SCT) with posttransplant cyclophosphamide (PTCy) as graftversus-<br> host disease (GVHD) prophylaxis, comparing outcomes based on pretransplant<br> exposure to checkpoint inhibitors (CPIs). Considering pretransplant characteristics, the<br> 2 cohorts (CPI 5 29 patients vs no-CPI 5 30 patients) were similar, except for the number<br> of prior lines of therapy (6 vs 4; P , .001). With a median follow-up of 26 months (range,<br> 7.5-55 months), by univariate analysis, the 100-day cumulative incidence of grade 2-4 acute GVHD<br> was 41% in the CPI group vs 33% in the no-CPI group (P 5 .456), whereas the 1-year cumulative<br> incidence of moderate to severe chronicGVHDwas 7%vs 8%, respectively (P 5 .673). In the CPI<br> cohort, the 2-year cumulative incidence of relapse appeared lower compared with the no-CPI<br> cohort (0 vs 20%; P 5 .054). No differences were observed in terms of overall survival (OS),<br> progression-free survival (PFS), and nonrelapse mortality (NRM) (at 2 years, 77% vs 71%<br> [P 5 .599], 78% vs 53% [P 5 .066], and 15% vs 21% [P 5 .578], respectively). By<br> multivariable analysis, CPI before SCT was an independent protective factor for PFS<br> (hazard ratio [HR], 0.32; P 5 .037). Stable disease (SD)/progressive disease (PD) was an<br> independent negative prognostic factor for both OS and PFS (HR, 14.3; P , .001 and HR,<br> 14.1; P , .001, respectively) . In conclusion, CPI as a bridge to haplo-SCT seems to improve<br> PFS, with no impact on toxicity profile.