Comprehensive methylome sequencing reveals prognostic epigenetic biomarkers for prostate cancer mortality

We profiled DNA from primary tumour RP tissue specimens from 15 patients (and adjacent normal tissue specimens from 4 patients) in a discovery cohort using whole-genome bisulphite sequencing (WGBS). We identified a set of differentially methylated regions in the primary tumour samples between patients who died ≤ 10 yrs post-RP and those still alive > 10 yrs post RP (median follow-up time: 19.5 years). We used WGBS data to detect methylation differences in tumours from patients with lethal (n = 7) and non-lethal (n = 8) disease. 'GSE158927_BigTable.tsv.gz’ is a tsv file providing coverage and methylation data for each sample (columns) at each CpG site (rows). In the column names, chr = chromosome, position = genomic position, then for each sample, C = count methylated and cov = total coverage