Estimates of variants replication rate relative to wild-type HCV (<i>f</i>) and corresponding predictions of their pre-dosing prevalence.

aOnly variants detected for more than one subject are shown. bNumber of subjects from whose data variant fitness was estimated. cIC50 values were measured in replicon cells; (L) variant with low-level resistance; (H) variant with high-level resistance. dMean and standard deviation (SD) computed among subjects. eThe precision of the fitness estimates, standard deviation (SD) of the estimation error in the point estimates of optimal parameter values, was calculated for each subject. The median and range was reported among subjects. N.a. not available (because the optimal value is at lower bound). f95% confidence intervals were computed only for variants whose fitness was estimated from more than 5 subjects. gIn the estimation, the IC50 of T54S was assumed to be the same as that of T54A. hIn the estimation, the IC50 of V36M/T54S was assumed to be the same as that of V36M/R155K.