Antimicrobial activity of a synthetic brevibacillin analog against multidrug-resistant Campylobacter spp.

We investigated the antimicrobial potential of a chemically synthesized brevibacillin analog against a small collection of 44 clinical Campylobacter spp. The brevibacillin analog that we chemically synthesized is derived from a linear lipopeptide naturally produced by Brevibacillus laterosporus. The peptide was active against multi-resistant isolates with a bactericidal effect. Of note, despite numerous attempts, it proved impossible to select Campylobacter spp. for resistance to the brevibacillin analog. These results underline the potential of lipopeptides, notably brevibacillin, as antimicrobial alternatives against antibiotic-resistant Campylobacter bacterial infections.