Potential use of additivity of mutational effects in simplifying protein engineering.
收藏PubMed Central1996-10-01 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC38227/
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资源简介：
The problem of rationally engineering protein molecules can be simplified where effects of mutations on protein function are additive. Crystal structures of single and double mutants in the hydrophobic core of gene V protein indicate that structural and functional effects of core mutations are additive when the regions structurally influenced by the mutations do not substantially overlap. These regions of influence can provide a simple basis for identifying sets of mutations that will show additive effects. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1996-10-01
