Genome-wide transcriptional analysis in intestinal biopsies from Crohn's disease (CD) patients.

Differential gene expression analysis between CD patients and controls to identify the transcriptional signature that defines the inflamed intestinal mucosa in CD. Intestinal biopsy samples were obtained from CD patients and healthy controls. RNA was subsequently extracted from each sample. Gene expression intensities were measured using GE Healthcare/Amersham Biosciences CodeLink Human Whole Genome Bioarray. After performing the gene expression quality control analysis, we characterized the transcriptional profile of the inflamed intestinal mucosa in CD.