Excitability profile of CA1 pyramidal neurons in APPPS1 Alzheimer disease mice and control littermates

In this study we analyzed the intrinsic electrophysiological properties of CA1 excitatory hippocampal neurons in a mouse model of Alzheimer’s Disease (AD) at two age points: a presymptomatic age (3-4 months) and a symptomatic age: (9-10 months). At this latter age, this APPPS1 model harbors amyloid plaques and hippocampus-dependent cognitive alterations. Little is known about the excitability alterations in the hippocampus that correlate to these cognitive deficits. Using patch clamp electrophysiology we recorded CA1 pyramidal neurons from control littermates (Wild types) and APPPS1 slices of hippocampus at these two age points. We provide these data for HBP users.