Bruton's tyrosine kinase with mutations in the activation loop in complex with compound P301390

Bruton's tyrosine kinase with mutations in the activation loop in complex with compound P301390 Descriptor: 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Tyrosine-protein kinase BTK Authors: Lin, D.Y, Andreotti, A.H, Tonge, P.J, Bravo, E, Li, X. Deposit date: 2024-12-06 Release date: 2025-08-13 Last modified: 2025-08-20 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Modulating the Binding Kinetics of Bruton's Tyrosine Kinase Inhibitors through Transition-State Effects. J.Am.Chem.Soc., 147, 2025