Identification of kidney transplant patients at risk for cutaneous squamous cell carcinoma by differentially methylated regions in T cells (II)

We aim to discover differentially methylated regions (DMRs) in peripheral T cells involved in de novo cSCC development after kidney transplantation. This was a retrospective study on biobank patient material. We matched kidney transplant patients with (future) cSCC to those without cSCC and studied genome-wide DNA methylation (450k arrays) of T cells after transplantation but prior to the clinical onset of the first cSCC. Pure T cell samples of 38 patients were analyzed. No replicates are included, all samples are unique. Kidney transplant patients with a (future) cSCC were matched to control kidney transplant patients without cSCC.