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G0 marker-separation of dormant and active hematopoietic stem cells reveals dormancy regulation by basal cytoplasmic calcium
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2019-12-19
相关数据集
Discrimination of dormant and active hematopoietic stem cells by G0 markers reveals dormancy regulation by cytoplasmic calcium
Quiescent hematopoietic stem cells (HSCs) are typically dormant, and only a few quiescent HSCs are active. The relationship between “dormant” and “active” HSCs remains unresolved. Here we generated a
NIAID Data Ecosystem120
CD38 enzymatic activity promotes hematopoietic stem cell dormancy [scRNA-Seq]. CD38 enzymatic activity promotes hematopoietic stem cell dormancy [scRNA-Seq]
Quiescence is a fundamental property that protects hematopoietic stem cells’ (HSCs) function throughout life. A subpopulation of deeply quiescent, so-called dormant HSCs (dHSCs) harbors the highest lo
NIAID Data Ecosystem70
Concerted roles of PTEN and ATM in controlling hematopoietic stem cell fitness and dormancy. Concerted roles of PTEN and ATM in controlling hematopoietic stem cell fitness and dormancy
In order to sustain proficient life-long hematopoiesis, hematopoietic stem cells (HSCs) must possess robust mechanisms to preserve their quiescence and genome integrity. DNA-damaging stress can pertur
NIAID Data Ecosystem40
Comparison of aged dormant and active hematopoietic stem cells
4 months old Scl-tta; H2B-GFP mice where chased with Doxycyclin for 18 months from and then sacrificed at 22 months of age. GFP+ and GFP- cells, or dormant and active HSCs were then sorted and sequenc
NIAID Data Ecosystem80
A critical requirement for IκBα in controlling dormancy in Hematopoietic stem cells via retinoic acid during embryonic development [Cut&Tag]. A critical requirement for IκBα in controlling dormancy in Hematopoietic stem cells via retinoic acid during embryonic development [Cut&Tag]
Hematopoietic Stem Cells (HSCs) originate from the E11.5 aorta-gonads-and mesonephros (AGM) region during development before they migrate to the foetal liver for proliferation and maturation, and fina
NIAID Data Ecosystem60
