Identification of cis-regulatory elements affecting pancreatic Islet maturation using chromatin accessibility variations

we were able to find several known and unforeseen key transcriptional regulators acting at cis-regulatory sites and promoters which depicted a differential accessibility and induced differential gene expression along maturation.我们成功鉴定出多种已知及未被预见的关键转录调控因子，它们作用于顺式调控元件（cis-regulatory sites）与启动子区域；这些位点在细胞成熟进程中呈现出差异可及性特征，并诱导了差异基因表达。