Supplementary Data for \"Ultimate paths of least resistance: Intrinsically disordered proteins as developmental resets in regulatory networks\"

DATA FILES OVERVIEW This repository features the data for the paper \"Ultimate paths of least resistance: Intrinsically disordered proteins as developmental resets in regulatory networks\", which can be found TBD. The manuscript examines how IDP links act as developmental resets in development and evolution This data repository consists of 33 data files described below: Data files and variables: 1. Supplementary Data 1a.txt: Morphology and protein expression data for n=2,792362 pre-condensation mesenchymal cells from which the main dataset is selected. TF - IHC protein assay Name - EmbryoID Stage- Developmental Stage (HH) Section - Slide section Run - IHC run GridID - Image Grid ID CellID -- Cell ID Area -- cell Area X,Y -- coordinates of cell centroid Perim -- Cell perimeter BX,BY -- the coordinates of the upper left corner of the rectangle enclodsing cell Width,Height - dimensions of rectangle enclosing cell Major,Minor -- major and minor axes of epipsoid enclosing cell Angle -- angle between elipsoid axes Circ - circularity Feret - feret length FeretX,FeretY - feret coordinates FeretAngle - feret angle (major axis) MinFeret -- feret angle (minor axis) AR - aspect ratio Round - roundness Solidity-solidity 2. Supplementary Data 1b.xlsx: Summary of cell morphology and protein expression for n =5,886 grid boxes with pre-condensation mesenchymal cells and associated data on developmental stage, population, IHC run and section ID GridID GridID (10x10) TF Protein Name EmbryoID Stage HH Developmental Stage Section Section ID Run Run ID Exp For all: UMES-undifferentiated mesenchyme Area_Mean Mean values for all cells in the grid box Perim_Mean Mean values for all cells in the grid box Width_Mean Mean values for all cells in the grid box Height_Mean Mean values for all cells in the grid box Major_Mean Mean values for all cells in the grid box Minor_Mean Mean values for all cells in the grid box Angle_Mean Mean values for all cells in the grid box Circ_Mean Mean values for all cells in the grid box Feret_Mean Mean values for all cells in the grid box FeretAngle_Mean Mean values for all cells in the grid box MinFeret_Mean Mean values for all cells in the grid box AR_Mean Mean values for all cells in the grid box Shape_Mean Mean values for all cells in the grid box Round_Mean Mean values for all cells in the grid box Solidity_Mean Mean values for all cells in the grid box Area_Var Variance for all cells in the grid box Perim_Var Variance for all cells in the grid box Width_Var Variance for all cells in the grid box Height_Var Variance for all cells in the grid box Major_Var Variance for all cells in the grid box Minor_Var Variance for all cells in the grid box Angle_Var Variance for all cells in the grid box Circ_Var Variance for all cells in the grid box Feret_Var Variance for all cells in the grid box FeretAngle_Var Variance for all cells in the grid box MinFeret_Var Variance for all cells in the grid box AR_Var Variance for all cells in the grid box Shape_Var Variance for all cells in the grid box Round_Var Variance for all cells in the grid box Solidity_Var Variance for all cells in the grid box Area_CV Coefficient of variation for all cells in the grid box Perim_CV Coefficient of variation for all cells in the grid box Width_CV Coefficient of variation for all cells in the grid box Height_CV Coefficient of variation for all cells in the grid box Major_CV Coefficient of variation for all cells in the grid box Minor_CV Coefficient of variation for all cells in the grid box Angle_CV Coefficient of variation for all cells in the grid box Circ_CV Coefficient of variation for all cells in the grid box Feret_CV Coefficient of variation for all cells in the grid box FeretAngle_CV Coefficient of variation for all cells in the grid box MinFeret_CV Coefficient of variation for all cells in the grid box AR_CV Coefficient of variation for all cells in the grid box Shape_CV Coefficient of variation for all cells in the grid box Round_CV Coefficient of variation for all cells in the grid box Solidity_CV Coefficient of variation for all cells in the grid box Area_StdErr StandardError for all cells in the grid box Perim_StdErr StandardError for all cells in the grid box Width_StdErr StandardError for all cells in the grid box Height_StdErr StandardError for all cells in the grid box Major_StdErr StandardError for all cells in the grid box Minor_StdErr StandardError for all cells in the grid box Angle_StdErr StandardError for all cells in the grid box Circ_StdErr StandardError for all cells in the grid box Feret_StdErr StandardError for all cells in the grid box FeretAngle_StdErr StandardError for all cells in the grid box MinFeret_StdErr StandardError for all cells in the grid box AR_StdErr StandardError for all cells in the grid box Shape_StdErr StandardError for all cells in the grid box Round_StdErr StandardError for all cells in the grid box Solidity_StdErr StandardError for all cells in the grid box Area_StdDev...