Pd-Catalyzed Regiodivergent Synthesis of Diverse Oxindoles Enabled by the Versatile Heck Reaction of Carbamoyl Chlorides

We report herein
a miscellaneous oxindole synthesis bearing an
all-carbon quaternary center, enabled by Pd-catalyzed intramolecular
cyclization followed by multiple intermolecular Heck reactions of
both easily accessible alkene-tethered carbamoyl chlorides and olefins.
This protocol obviates the use of prefunctionalized olefinic reagents,
exhibits excellent functional group tolerance, and features fascinating
reactive versatility.