Profile of protein-coding and long non-coding RNA expression and their clinical importance in T-cell acute lymphoblastic leukemia

We analyzed the prognostic relevance of immunophenotype,expression pattern of protein coding genes, epigenetic modifiers and long non-coding RNAs in T-ALL. A total of 134 T-ALL cases diagnosed by morphology, cytochemistry and immunophenotyping, were enrolled in this study. The T-ALL patients were divided into 2 cohorts: Discovery (n=35) and Validation (n=99). Total RNA seq was performed in the Discovery cohort.