Genome-wide analysis of sphingosine-1-phosphate receptor-1 (S1PR1)-dependent gene expression in tumor-associated macrophages. Mus musculus

The study was designed to identify a common set of genes under the control of S1PR1 in CD11b-high macrophages from both oncogene-induced breast tumors (PyMT) or carcinogen-induced fibrosarcomas (MCA). The goal was to identify common regulators of lymphangiogenesis in both models. Overall design: Total RNA from FACS-sorted wildtype or S1PR1 knockout CD11b-high macrophages of PyMT and MCA tumors