Differences in Schneider entropy values between the median distance of selected tunnel-lining residues and the median distances of the remaining positions of the trimmed Multiple Sequence Alignment (MSA).

Negative values indicate compartments with lower variability and positive values indicate compartments with higher variability than the remaining positions of the trimmed MSA. Table consists of: the MD simulation tunnel ranking (MDRank), tunnel name, its average length, number of tunnel-lining residues, number of tunnel-lining residues without the surface residues, number of surface tunnel-lining residues, and the last three columns comprise of the differences between the median distances of particular tunnel-lining residues and the remaining positions of the trimmed MSA: median distances of tunnel-lining residues (7th column), median distances of the tunnel-lining residues without the surface residues (8th column), and median distances of the surface tunnel-lining residues (9th column). Differences between median distances values that are marked bold passed the statistical significance of the Epps-Singleton two-sample test (p-value (XLSX)