Concurrent Activation of Kras and Canonical Wnt Signaling Induces Premalignant Lesions That Progress to Extrahepatic Biliary Cancer in Mice. Concurrent Activation of Kras and Canonical Wnt Signaling Induces Premalignant Lesions That Progress to Extrahepatic Biliary Cancer in Mice
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA789569
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We revealed that concurrent activation of the Kras and canonical Wnt pathways resulted in formation of ICPN and BilIN, which could develop into biliary cancer. We found that c-Myc contributed to tumorigenesis, whereas Tgf-β pathway inhibited it. Overall design: Hnf1bCreER, Hnf1bCreER;Kras, Hnf1bCreER;Ctnnb1, and Hnf1bCreER;Kras;Ctnnb spheroids were analyzed (n=3/group).
创建时间：
2021-12-16
