New pipeline for a multi-antigen vaccine strategy that includes non-Spike proteins to expand cross-reactive immunity across a broader spectrum of Betacoronaviruses.

NIAID Data Ecosystem40

Cryo-EM structure of SARS-CoV-2 Spike trimer S2D14 with two RBDs exposed

病毒结构生物学

疫苗抗原设计

Cryo-EM structure of SARS-CoV-2 Spike trimer S2D14 with two RBDs exposed Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D

Protein Data Bank Japan2025-05-28 更新30

Antigenic characterization of the human immunodeficiency virus (HIV-1) envelope glycoprotein precursor incorporated into nanodiscs

疫苗抗原设计

膜蛋白纳米盘重构

The entry of human immunodeficiency virus (HIV-1) into host cells is mediated by the viral envelope glycoproteins (Envs), which are derived by the proteolytic cleavage of a trimeric gp160 Env precurso

NIAID Data Ecosystem40

Different Pattern of Immunoglobulin Gene Usage by HIV-1 Compared to Non-HIV-1 Antibodies Derived from the Same Infected Subject

HIV抗体基因工程

疫苗抗原设计

A biased usage of immunoglobulin (Ig) genes is observed in human anti-HIV-1 monoclonal antibodies (mAbs) resulting probably from compensation to reduced usage of the VH3 family genes, while the other

Figshare2016-01-19 更新30

Cross-reactive SARS-CoV-2 epitope targeted across donors informs immunogen design. Hauser et al

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