Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis

To further explore the role of HDAC8 in NEC, we analyzed the signaling pathways that were altered in mice with NEC. We then performed gene expression profiling analysis using data obtained from RNA-seq of intestinal tissues (control group, NEC group). Overall design: Comparative gene expression profiling analysis of RNA-seq data for intestinal tissues from control or NEC mice.