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AngII induced responses from non-myocytes in the heart

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https://www.ncbi.nlm.nih.gov/sra/SRP341053
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AngII infusion in mouse is a classic model of cardiac hypertrophy. Here we aimed to understand how non-myocytes in the myocardium respond to AngII stimulation. Overall design: Lyz2-Cre and Lyz2-KLF2-KO mice were subjected to AngII infusion at the dose of 1.0 ug/kg/min for one week. CD45+ and CD31+ cells were sorted from the heart, and subjected to single cell capture by 10X genomics device and followed by RNA-seq using Illumina platform.
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2022-02-15
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