Crystal structure of CSF1R kinase domain in complex with DP-6233
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Crystal structure of CSF1R kinase domain in complex with DP-6233 Descriptor: 2,2-dimethyl-N-[(6-methyl-5-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}pyridin-2-yl)carbamoyl]propanamide, CHLORIDE ION, Macrophage colony-stimulating factor 1 receptor,Fibroblast growth factor receptor 1 chimera, ... Authors: Edwards, T.E, Arakaki, T.L, Chun, L, Flynn, D.L. Deposit date: 2022-01-21 Release date: 2022-08-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors. Bioorg.Med.Chem.Lett., 74, 2022
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2022-01-21
